The clinical development of MEK inhibitors

2024-12-23 09:38:58 | mek

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• 2024-12-12 19:30 DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells - ScienceDirect.com
• 2024-09-09 07:00 Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage - Nature.com
• 2024-12-02 12:43 MEK Inhibitors Strategic Business Research Report - GlobeNewswire
• 2024-07-30 04:07 MEK’s shadow in European Parliament - Responsible Statecraft
• 2024-06-20 07:00 MEK Leaders May Be Extradited to Iran, Judiciary Official Says - ایران اینترنشنال
• 2024-07-01 09:39 MEK inhibitors: a promising targeted therapy for cardiovascular disease - Frontiers
• 2024-11-20 08:00 Study Compares Skin Toxicities of MEK Inhibitors in Children - Medscape
• 2024-12-13 11:30 Extension for the Project on the Sámi Collection at MEK until November 2025 - Staatliche Museen zu Berlin
• 2024-10-29 07:00 Successful treatment of metastatic malignant glomus tumor with BRAF and MEK inhibitors - News-Medical.Net
• 2024-10-22 07:00 MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB - Nature.com
• 2024-09-05 07:06 Echinatin alleviates sepsis severity through modulation of the NF-κB and MEK/ERK signaling pathways - ScienceDirect.com
• 2024-06-21 07:36 Apigenin potentiates glucose-stimulated insulin secretion through the PKA-MEK kinase signaling pathway independent of K-ATP channels - ScienceDirect.com
• 2024-09-05 07:00 Efficacy of PARP inhibitor therapy after targeted BRAF/MEK failure in advanced melanoma | npj Precision Oncology - Nature.com
• 2024-10-29 07:00 Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway - Nature.com
• 2024-05-24 18:45 The natural compound ugonin V targets MMP7 production and restricts chondrosarcoma metastasis by suppressing the MEK/ERK/c-Jun signaling pathways - ScienceDirect.com
• 2024-04-10 07:00 CDK4/6 inhibition sensitizes MEK inhibition by inhibiting cell cycle and proliferation in pancreatic ductal adenocarcinoma | Scientific Reports - Nature.com
• 2024-05-15 07:00 Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies - Nature.com
• 2024-02-26 08:00 Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRAS - Nature.com
• 2024-04-06 07:00 The prognostic value of MEK pathway–associated estrogen receptor signaling activity for female cancers - Nature.com
• 2024-11-12 08:00 TIPE2 inhibits melanoma progression through MEK/ERK signaling - Nature.com
• 2024-02-22 08:00 The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction - Nature.com
• 2024-10-01 07:00 FOXM1 and PD-L1 in CDK4/6-MEK resistance in nerve tumors - EurekAlert
• 2024-11-14 02:26 Figure 1. Voie de signalisation des MAP-kinases, avec les voies... - ResearchGate
• 2024-11-08 08:00 Activation of MEK‐ERK‐c‐MYC signaling pathway promotes splenic M2-like macrophage polarization to inhibit PHcH-liver cirrhosis - Frontiers
• 2024-12-09 17:03 Early December Scenario: MEK Prices Takes Pressure of Low Demand and Global Supply Excess - ChemAnalyst
• 2024-08-13 07:00 Peptidomic analysis reveals novel peptide PDLC promotes cell proliferation in hepatocellular carcinoma via Ras/Raf/MEK/ERK pathway - Nature.com
• 2024-08-21 07:00 ZOTAC GAMING Reveals MEK HERO Gaming PC Deals at Amazon This August Starting at Just $1,011.39 - PR Web
• 2024-10-24 07:00 Cardiotoxicity of BRAF/MEK Inhibitors Mimicking Apical Hypertrophic Cardiomyopathy - Cureus
• 2024-06-24 07:00 MEK-inhibitor treatment reduces the induction of regulatory T cells in mice after influenza A virus infection - Frontiers
• 2024-02-15 06:41 Comparison of responses of human melanoma cell lines to MEK and BRAF inhibitors - Frontiers
• 2024-01-22 08:00 A MEK inhibitor arrests the cell cycle of human conjunctival fibroblasts and improves the outcome of glaucoma filtration surgery - Nature.com
• 2024-05-01 07:00 Effect of NFX-179 MEK inhibitor on cutaneous neurofibromas in persons with neurofibromatosis type 1 - Science
• 2024-08-20 07:00 Targeting PI3K/AKT and MEK/ERK pathways for synergic effects on improving features of peripheral diabetic neuropathy - Wiley Online Library
• 2024-06-26 07:00 MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells - Science
• 2024-02-16 02:52 Neoadjuvant B-RAF and MEK Inhibitor Targeted Therapy for Adult Papillary Craniopharyngiomas: A New Treatment Paradigm - Frontiers
• 2024-05-10 07:00 Classical prescription Floris Sophorae Powder treat colorectal cancer by regulating KRAS/MEK-ERK signaling pathway - ScienceDirect.com
• 2024-07-28 07:00 Exiled Iranian dissidents welcome UN's call for investigation into 1980s purge - RFI English
• 2024-06-07 07:00 Major cause of inflammatory bowel disease discovered - Imperial College London
• 2024-03-13 07:00 Donors to Bob Menendez Legal Defense Linked to Ex-Terror Group - The Intercept
• 2024-06-13 07:00 Atriva Therapeutics Secures Us Patent for Mek Inhibitor Zapnometinib (Atr-002) - Technology Networks
• 2024-09-22 07:00 MEK Menopause Special Focus Day on 22 September 2024: It’s far from over! - Staatliche Museen zu Berlin
• 2024-02-29 08:00 Cysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer - Nature.com
• 2024-01-21 08:00 Dual inhibition of MEK and PI3Kβ/δ–a potential therapeutic strategy in PTEN-wild-type docetaxel-resistant metastatic prostate cancer - Frontiers
• 2024-12-22 13:52 A Test of Endurance: Cyber Assaults and the Iranian Resistance’s Marathon Toward Change - National Council of Resistance of Iran (NCRI)
• 2024-11-15 08:00 MEK Inhibitor Scores Big Win in Adults, Children With Neurofibromatosis Type 1 - Medpage Today
• 2024-09-11 07:00 Clinical Mic Drop: The Latest Innovations on MEK Therapies for Neurofibromatosis Type 1-Associated Plexiform Neurofibromas - PRIME® Continuing Medical Education
• 2024-09-02 11:49 Muslim InVisibilities at the Museum Europäischer Kulturen (MEK) - Staatliche Museen zu Berlin
• 2024-05-20 07:00 Dr Salani on Research With MEK Inhibition in KRAS-Mutant Serous Ovarian Cancer - OncLive
• 2024-08-22 07:00 Here's Why We're Watching Meeka Metals' (ASX:MEK) Cash Burn Situation - Yahoo Finance
• 2024-04-18 07:00 Multi-omics-based investigation of Bifidobacterium’s inhibitory effect on glioma: regulation of tumor and gut microbiota, and MEK/ERK cascade - Frontiers
• 2024-08-21 07:00 Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1H-benzo[d]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the “Clamp” Strategy - ACS Publications
• 2024-01-18 08:00 Rapid diurnal variation of serous retinal detachment during BRAF and MEK inhibitor treatment: A case series - Wiley Online Library
• 2024-01-15 08:00 RNF43 Inactivation Enhances the B-RAF/MEK Signaling and Creates a Combinatory Therapeutic Target in Cancer Cells - Wiley Online Library
• 2024-08-28 07:00 Erratum for the Research Article “MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells” by S. Perrin et al - Science
• 2024-09-27 07:00 PAS-004 Has Tolerable Safety Profile and Preliminary Efficacy in MAPK-Driven Solid Tumors - OncLive
• 2024-08-23 00:42 The Küppers Collection at MEK - Staatliche Museen zu Berlin
• 2024-08-22 10:20 Online Presentation: Traces of European Muslims in the MEK Collection - Staatliche Museen zu Berlin
• 2024-02-13 18:10 Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance - Frontiers
• 2024-07-24 02:39 Mek Ah Step Goes to Bella Rehabilitation Centre - Crowdfunder UK
• 2024-11-13 08:00 High Supplies and Weak Demand Keep Asian MEK Market Under Pressure - ChemAnalyst
• 2024-07-25 07:00 Asian MEK Prices Inches-up in mid-July 2024 Amidst Market Volatility - ChemAnalyst
• 2021-03-30 07:00 PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK - ScienceDirect.com
• 2024-02-10 13:09 Case Report: Immune-Related Toxicity During Adjuvant Treatment With BRAF Plus MEK Inhibitors in a Melanoma Patient - Frontiers
• 2022-07-16 07:00 Iran blacklists US officials for supporting ‘terrorist’ group MEK - Al Jazeera English
• 2023-07-03 07:00 Iran condemns MEK rally in France as support for ‘terrorism’ - Al Jazeera English
• 2024-11-11 06:18 Facebook shuts down hundreds of fake profiles linked to the Iranian MEK group in Albania - Telegrafi
• 2022-07-14 07:00 Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression - Nature.com
• 2024-04-16 07:00 Japan's MEK Prices Decline Amidst Lower Costs, Soft Demand - ChemAnalyst
• 2024-10-26 07:00 Meeka Metals Limited (ASX:MEK) Is About To Turn The Corner - Simply Wall St
• 2023-07-12 07:00 BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas - nejm.org
• 2024-04-30 07:00 Surrender - by Mek - The Raptorial - substack.com
• 2023-06-21 07:00 Why was this Iran dissident group raided in Europe? - Al Jazeera English
• 2022-11-23 08:00 MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression - Nature.com
• 2024-01-16 08:00 Congress forms caucus to aid Iranian ex-terror group - Responsible Statecraft
• 2023-11-13 23:17 Bruceine A: Suppressing metastasis via MEK/ERK pathway and invoking mitochondrial apoptosis in triple-negative breast cancer - ScienceDirect.com
• 2023-04-06 07:00 MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ - Nature.com
• 2023-10-13 07:00 MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling - Nature.com
• 2024-09-17 07:00 Many new orders to Aas Mek Verksted - Maritimt Magasin
• 2023-06-27 07:00 Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma - ScienceDirect.com
• 2024-05-14 07:00 Iranian Regime MFA Spox Calls for Western Restrictions on MEK - National Council of Resistance of Iran (NCRI)
• 2019-05-16 07:00 MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer - Nature.com
• 2020-05-01 07:00 Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy - Nature.com
• 2019-03-13 07:00 Efficacy of MEK inhibition in patients with histiocytic neoplasms - Nature.com
• 2023-05-25 07:00 Histological transformation to gliosarcoma with combined BRAF/MEK inhibition in BRAF V600E mutated glioblastoma - Nature.com
• 2018-03-29 07:00 MEK’s violent past looms over US lobby for regime change in Iran - Al Jazeera English
• 2024-03-28 07:00 Nested Therapeutics Announces FDA Clearance of Investigational New Drug (IND) Application for NST-628, a Novel Pan-RAF/MEK Molecular Glue - BioSpace
• 2012-09-29 07:00 US removes Iran group MEK from terror list - BBC.com
• 2020-06-16 07:00 Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers - ScienceDirect.com
• 2018-11-06 08:00 BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association - ScienceDirect.com
• 2017-12-31 14:20 Murine Ksr interacts with MEK and inhibits Ras-induced transformation - ScienceDirect.com
• 2018-10-19 07:00 Targeting MEK in vemurafenib-resistant hairy cell leukemia - Nature.com
• 2019-03-04 08:00 Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers - Nature.com
• 2020-09-14 07:00 Structural basis for the action of the drug trametinib at KSR-bound MEK - Nature.com
• 2024-06-14 07:00 Opening of the Thung Maha Mek Fire and Rescue Station building, modern and ready to prevent disasters in the Yannawa and Sathorn areas. - กรุงเทพมหานคร, ประชาสัมพันธ์
• 2022-10-03 07:00 PD-L1 induction via the MEK-JNK-AP1 axis by a neddylation inhibitor promotes cancer-associated immunosuppression - Nature.com
• 2023-06-20 07:00 Albanian Police Raid Iranian Opposition MEK Camp | Iran International - ایران اینترنشنال
• 2024-06-23 07:00 Fact-Checking Le Monde: MEK’s Official Rebuttal - National Council of Resistance of Iran (NCRI)
• 2022-07-13 07:00 Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer - Nature.com
• 2012-06-04 07:00 Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma - nejm.org
• 2018-11-09 08:00 Terrorists, cultists – or champions of Iranian democracy? The wild wild story of the MEK - The Guardian

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The clinical development of MEK inhibitors

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The clinical development of MEK inhibitors

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