新發現：木香可解決癌症靶向治療的耐藥性問題

2024-12-22 23:44:20 | mek

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mek: 新發現：木香可解決癌症靶向治療的耐藥性問題

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2024-12-18 16:12 The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models - Nature.com
2024-12-12 19:30 DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells - ScienceDirect.com
2024-12-02 12:43 MEK Inhibitors Strategic Business Research Report - GlobeNewswire
2024-07-01 09:39 MEK inhibitors: a promising targeted therapy for cardiovascular disease - Frontiers
2024-06-20 07:00 MEK Leaders May Be Extradited to Iran, Judiciary Official Says - ایران اینترنشنال
2024-05-01 07:00 Effect of NFX-179 MEK inhibitor on cutaneous neurofibromas in persons with neurofibromatosis type 1 - Science
2024-07-30 04:07 MEK’s shadow in European Parliament - Responsible Statecraft
2024-11-20 08:00 Study Compares Skin Toxicities of MEK Inhibitors in Children - Medscape
2024-09-09 07:00 Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage - Nature.com

2024-09-05 07:06 Echinatin alleviates sepsis severity through modulation of the NF-κB and MEK/ERK signaling pathways - ScienceDirect.com
2024-06-26 07:00 MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells - Science
2024-10-22 07:00 MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB - Nature.com
2024-06-21 07:36 Apigenin potentiates glucose-stimulated insulin secretion through the PKA-MEK kinase signaling pathway independent of K-ATP channels - ScienceDirect.com
2024-05-24 18:45 The natural compound ugonin V targets MMP7 production and restricts chondrosarcoma metastasis by suppressing the MEK/ERK/c-Jun signaling pathways - ScienceDirect.com
2024-09-05 07:00 Efficacy of PARP inhibitor therapy after targeted BRAF/MEK failure in advanced melanoma | npj Precision Oncology - Nature.com
2024-04-10 07:00 CDK4/6 inhibition sensitizes MEK inhibition by inhibiting cell cycle and proliferation in pancreatic ductal adenocarcinoma | Scientific Reports - Nature.com
2024-05-15 07:00 Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies - Nature.com
2024-02-26 08:00 Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRAS - Nature.com
2024-04-06 07:00 The prognostic value of MEK pathway–associated estrogen receptor signaling activity for female cancers - Nature.com

2024-03-21 07:00 The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression - Nature.com
2024-11-12 08:00 TIPE2 inhibits melanoma progression through MEK/ERK signaling - Nature.com
2024-02-22 08:00 The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction - Nature.com
2024-12-22 13:52 A Test of Endurance: Cyber Assaults and the Iranian Resistance’s Marathon Toward Change - National Council of Resistance of Iran (NCRI)
2024-12-13 11:30 Extension for the Project on the Sámi Collection at MEK until November 2025 - Staatliche Museen zu Berlin
2024-11-08 08:00 Activation of MEK‐ERK‐c‐MYC signaling pathway promotes splenic M2-like macrophage polarization to inhibit PHcH-liver cirrhosis - Frontiers
2024-02-29 08:00 Cysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer - Nature.com
2024-08-28 07:00 Erratum for the Research Article “MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells” by S. Perrin et al - Science
2024-07-19 07:00 USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway - Nature.com
2024-05-31 07:00 Exceptional Response of BRAFV600E-Mutated Acinar Cell CUP to BRAF/MEK Inhibition | JCO Precision Oncology - ASCO Journals

2024-09-11 07:00 Clinical Mic Drop: The Latest Innovations on MEK Therapies for Neurofibromatosis Type 1-Associated Plexiform Neurofibromas - PRIME® Continuing Medical Education
2024-04-25 07:00 TMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression - Nature.com
2024-06-24 07:00 MEK-inhibitor treatment reduces the induction of regulatory T cells in mice after influenza A virus infection - Frontiers
2024-06-05 07:00 A disease-associated gene desert directs macrophage inflammation through ETS2 - Nature.com
2024-01-22 08:00 A MEK inhibitor arrests the cell cycle of human conjunctival fibroblasts and improves the outcome of glaucoma filtration surgery - Nature.com
2024-01-21 08:00 Dual inhibition of MEK and PI3Kβ/δ–a potential therapeutic strategy in PTEN-wild-type docetaxel-resistant metastatic prostate cancer - Frontiers
2024-02-05 16:19 Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma - Frontiers
2024-08-22 07:00 Here's Why We're Watching Meeka Metals' (ASX:MEK) Cash Burn Situation - Yahoo Finance
2024-09-22 07:00 MEK Menopause Special Focus Day on 22 September 2024: It’s far from over! - Staatliche Museen zu Berlin
2024-09-02 11:49 Muslim InVisibilities at the Museum Europäischer Kulturen (MEK) - Staatliche Museen zu Berlin

2024-05-20 07:00 Dr Salani on Research With MEK Inhibition in KRAS-Mutant Serous Ovarian Cancer - OncLive
2024-01-15 08:00 RNF43 Inactivation Enhances the B-RAF/MEK Signaling and Creates a Combinatory Therapeutic Target in Cancer Cells - Wiley Online Library
2024-01-18 08:00 Rapid diurnal variation of serous retinal detachment during BRAF and MEK inhibitor treatment: A case series - Wiley Online Library
2023-07-03 07:00 Iran condemns MEK rally in France as support for ‘terrorism’ - Al Jazeera English
2024-02-13 18:10 Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance - Frontiers
2023-06-21 07:00 Why was this Iran dissident group raided in Europe? - Al Jazeera English
2024-08-23 00:42 The Küppers Collection at MEK - Staatliche Museen zu Berlin
2024-08-22 10:20 Online Presentation: Traces of European Muslims in the MEK Collection - Staatliche Museen zu Berlin
2012-09-29 07:00 US removes Iran group MEK from terror list - BBC.com
2021-03-30 07:00 PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK - ScienceDirect.com

2022-07-16 07:00 Iran blacklists US officials for supporting ‘terrorist’ group MEK - Al Jazeera English
2019-11-27 20:23 Catalytic behavior and reaction routes of MEK oxidation over Pd/ZSM-5 and Pd–Ce/ZSM-5 catalysts - ScienceDirect.com
2014-07-28 07:00 Mujahadeen-e-Khalq (MEK) - Council on Foreign Relations
2022-04-07 07:00 MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment - Nature.com
2024-01-31 08:00 MEK Prices Surge Amid Supply Disruptions and Growing Demand in the Europe Market - ChemAnalyst
2018-03-29 07:00 MEK’s violent past looms over US lobby for regime change in Iran - Al Jazeera English
2022-07-14 07:00 Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression - Nature.com
2024-04-08 14:14 Áimmuin: Re-Connecting Sámi Heritage - Staatliche Museen zu Berlin
2023-11-13 23:17 Bruceine A: Suppressing metastasis via MEK/ERK pathway and invoking mitochondrial apoptosis in triple-negative breast cancer - ScienceDirect.com
2023-06-27 07:00 Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma - ScienceDirect.com

2022-11-23 08:00 MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression - Nature.com
2019-05-16 07:00 MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer - Nature.com
2023-04-06 07:00 MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ - Nature.com
2018-11-06 08:00 BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association - ScienceDirect.com
2017-12-31 14:20 Murine Ksr interacts with MEK and inhibits Ras-induced transformation - ScienceDirect.com
2023-10-13 07:00 MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling - Nature.com
2020-06-16 07:00 Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers - ScienceDirect.com
2019-03-13 07:00 Efficacy of MEK inhibition in patients with histiocytic neoplasms - Nature.com
2020-05-01 07:00 Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy - Nature.com
2020-12-17 08:00 MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes - Nature.com

2013-09-26 07:00 Concurrent MEK2 Mutation and BRAF Amplification Confer Resistance to BRAF and MEK Inhibitors in Melanoma - ScienceDirect.com
2023-10-30 07:00 Former MEK leader Massoud Rajavi died under US guard, say Iran media - Al Jazeera English
2018-10-19 07:00 Targeting MEK in vemurafenib-resistant hairy cell leukemia - Nature.com
2019-03-04 08:00 Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers - Nature.com
2023-05-25 07:00 Histological transformation to gliosarcoma with combined BRAF/MEK inhibition in BRAF V600E mutated glioblastoma - Nature.com
2016-02-26 08:00 MEK inhibitor, TAK-733 reduces proliferation, affects cell cycle and apoptosis, and synergizes with other targeted therapies in multiple myeloma - Nature.com
2020-09-14 07:00 Structural basis for the action of the drug trametinib at KSR-bound MEK - Nature.com
2023-11-02 07:00 Live-cell target engagement of allosteric MEKi on MEK–RAF/KSR–14-3-3 complexes - Nature.com
2019-12-09 08:00 MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia - Nature.com
2020-12-08 08:00 MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK - Nature.com

2022-10-03 07:00 PD-L1 induction via the MEK-JNK-AP1 axis by a neddylation inhibitor promotes cancer-associated immunosuppression - Nature.com
2015-06-05 07:00 MEK inhibitors: a new class of chemotherapeutic agents with ocular toxicity - Nature.com
2022-07-13 07:00 Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer - Nature.com
2023-06-20 07:00 Albanian Police Raid Iranian Opposition MEK Camp | Iran International - ایران اینترنشنال
2022-10-13 07:00 An Approach for Modeling, Simulation, and Optimization of Catalytic Production of Methyl Ethyl Ketone - Wiley Online Library
2019-11-18 08:00 Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases - Nature.com
2021-07-24 07:00 Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF -mutant melanoma - Nature.com
2019-03-04 08:00 MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells - Nature.com
2023-01-26 08:00 Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial | Nature Medicine - Nature.com
2022-05-25 07:00 Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma - Nature.com

2019-07-26 07:00 Global view of the RAF-MEK-ERK module and its immediate downstream effectors - Nature.com
2021-12-21 08:00 MEK inhibition exerts temporal and myeloid cell-specific effects in the pathogenesis of neurofibromatosis type 1 arteriopathy - Nature.com
2014-04-10 07:00 Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3 - ScienceDirect.com
2021-09-01 01:33 Targeting enhancer reprogramming to mitigate MEK inhibitor resistance in preclinical models of advanced ovarian cancer - JCI
2023-01-26 08:00 Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors | Cell Death & Disease - Nature.com
2018-10-16 07:00 PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation - ScienceDirect.com
2021-02-12 08:00 Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor - Nature.com
2019-04-16 07:00 Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer - ScienceDirect.com
2018-11-09 08:00 Terrorists, cultists – or champions of Iranian democracy? The wild wild story of the MEK - The Guardian
2020-09-08 07:00 MEK Inhibitors for the Treatment of Low-Grade Serous Ovarian Cancer: Expanding Therapeutic Options for a Rare Ovarian Cancer Subtype | Journal of Clinical Oncology - ASCO Journals

2020-05-04 07:00 The limitations of targeting MEK signalling in Glioblastoma therapy - Nature.com

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新發現：木香可解決癌症靶向治療的耐藥性問題

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