HIF-PH阻害薬、1位のダプロデュスタットがシェア5割を突破

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hif: HIF-PH阻害薬、1位のダプロデュスタットがシェア5割を突破

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2024-09-03 07:00 Citrullination modulation stabilizes HIF-1α to promote tumour progression - Nature.com
2024-09-24 07:00 A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein - ScienceDirect.com
2024-05-16 07:00 HIF Global selects Johnson Matthey’s methanol technology for the largest e methanol plant in South America - Johnson Matthey
2024-09-20 07:00 MOL Invests in HIF Global, a U.S.-based company of e-Fuels -Toward the Decarbonization of the Mobility Industry with synthetic fuels - - 株式会社商船三井
2024-10-21 07:00 Discovery of ZG-2305, an Orally Bioavailable Factor Inhibiting HIF Inhibitor for the Treatment of Obesity and Fatty Liver Disease - ACS Publications
2024-09-11 07:00 HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis - Science
2024-06-26 07:00 A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity - Wiley Online Library
2024-09-14 07:00 HIF-2α- dependent induction of miR-29a restrains T - Nature.com
2024-05-31 20:06 Stilbenoid derivatives as potent inhibitors of HIF-1α-centric cancer metabolism under hypoxia - ScienceDirect.com

2024-08-28 07:00 Pharmacologic HIF stabilization activates costimulatory receptor expression to increase antitumor efficacy of adoptive T cell therapy - Science
2024-06-27 07:00 Targeting HIF-1 to treat AML - Nature.com
2024-02-27 08:00 The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation - ScienceDirect.com
2024-07-24 07:00 HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma - Nature.com
2024-05-16 02:04 HIF-1α Mediates Immunosuppression and Chemoresistance in Colorectal Cancer by Inhibiting CXCL9, −10 and −11 - ScienceDirect.com
2024-04-18 07:00 The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia - Nature.com
2024-09-19 07:00 The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma - Nature.com
2024-03-12 07:00 The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair | Bone Research - Nature.com
2024-06-04 07:00 Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α - Nature.com
2024-11-25 08:00 FBP1 over-expression suppresses HIF-1α in papillary thyroid cancer - Nature.com

2024-11-23 08:00 Association of serum HIF-1α levels with coronary artery calcification in patients of non-dialysis chronic kidney disease - Nature.com
2024-06-25 03:45 Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine - Frontiers
2024-05-15 07:00 Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway - Nature.com
2024-02-13 08:00 Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin - Nature.com
2024-06-11 07:00 DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer - Nature.com
2024-08-22 07:00 From Bench to Bedside: HIF-2α Inhibition in RCC - OncLive
2024-08-06 07:00 Hif-2α programs oxygen chemosensitivity in chromaffin cells - JCI
2024-03-19 07:00 MOL, Idemitsu, HIF Team up to Develop e-fuel/e-methanol Supply Chain, Including Marine Transport of CO - 株式会社商船三井
2024-11-14 08:00 Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation - Nature.com
2024-06-05 07:00 HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model - Nature.com

2024-08-23 07:00 LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia - Nature.com
2024-06-26 07:00 A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity - Wiley Online Library
2024-06-26 03:12 The Interplay Between Tumor Suppressor p53 and Hypoxia Signaling Pathways in Cancer - Frontiers
2024-10-04 07:00 MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice - Nature.com
2024-11-11 08:00 Abstract 4138199: Examining the regulating mechanism of the HIF-FOXM1 axis in promoting adult pig cardiomyocyte proliferation - AHA Journals
2024-07-01 07:00 Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ - Nature.com
2024-08-26 07:00 Letter by Sun and Ren Regarding Article, “MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy” | Circulation - AHA Journals
2024-05-29 07:00 Design and Synthesis of Quinoxaline Hybrids as Modulators of HIF-1a, VEGF, and p21 for Halting Colorectal Cancer - ACS Publications
2024-10-14 07:00 Unveiling the proteome of the fasting heart: Insights into HIF-1 pathway regulation - Frontiers
2024-09-02 07:00 Magnamosis improves the healing of gastrojejunal anastomosis and down-regulates TGF-β1 and HIF-1α in rats - Nature.com

2018-06-29 07:00 Hamilton's future secured - Hamilton City Council
2024-01-23 08:00 Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ - ScienceDirect.com
2024-05-17 07:54 Exploring the Role of HIF-2α Inhibition in Advanced Clear Cell Renal Cell Carcinoma - ASCO Daily News
2024-02-16 08:00 HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process - Nature.com
2024-05-17 07:00 JAM3 promotes cervical cancer metastasis by activating the HIF-1α/VEGFA pathway - BioMed Central
2024-09-19 07:00 Latham & Watkins Advises HIF Global on Investment by MOL - Latham & Watkins LLP
2024-01-20 08:00 Linking HIF oxygen-sensing system diversity to hypoxia fitness in Eleutheronema: Molecular characterization and transcriptional response to hypoxia exposure - ScienceDirect.com
2024-08-13 07:00 Latham Watkins Advises HIF Global on US36 Million Equity Investment Japan Organization Metals Energy - Latham & Watkins LLP
2024-02-15 08:00 PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer - Frontiers
2024-01-09 08:00 Hsa_circ_0081065 exacerbates IH-induced EndMT via regulating miR-665/HIF-1α signal axis and HIF-1α nuclear translocation - Nature.com

2024-02-12 09:16 UDCA Inhibits Hypoxic Hepatocellular Carcinoma Cell–Induced Angiogenesis Through Suppressing HIF-1α/VEGF/IL-8 Intercellular Signaling - Frontiers
2024-02-27 08:00 JFE Steel Corporation - jfe-steel.co.jp
2024-07-29 07:00 HIF Global and Airbus Partner to Develop E-SAF via Methanol to Jet Fuel - ChemAnalyst
2017-11-29 05:52 HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia - ScienceDirect.com
2023-08-09 07:00 Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells - Nature.com
2016-08-26 07:00 Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases - Nature.com
2017-12-12 04:19 HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption - ScienceDirect.com
2022-06-20 07:00 The effect of HIF on metabolism and immunity - Nature.com
2022-10-08 07:00 HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis | Cell Death & Disease - Nature.com
2020-01-31 08:00 Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model - Nature.com

2021-12-08 04:04 Hydrologic Instrumentation Facility (HIF) - United States Geological Survey
2023-11-23 08:00 Long-term HIF-1α stabilization reduces respiration, promotes mitophagy, and results in retinal cell death - Nature.com
2023-05-24 07:00 Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy - Nature.com
2023-07-27 07:00 A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress - Nature.com
2023-08-29 07:00 14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer - ScienceDirect.com
2022-12-06 08:00 HIF Global engages Bechtel, Siemens Energy, and Topsoe for eFuels project in the USA - Bechtel
2021-07-14 07:00 The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling - Nature.com
2023-12-17 01:54 DPP-4i versus SGLT2i as modulators of PHD3/HIF-2α pathway in the diabetic kidney - ScienceDirect.com
2023-06-10 07:00 Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function - Journal of Translational Medicine
2022-03-05 03:12 Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity - pnas.org

2018-11-26 08:00 HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts - Nature.com
2019-01-16 08:00 HIF-1α metabolically controls collagen synthesis and modification in chondrocytes - Nature.com
2019-01-10 08:00 Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-altitude ducks - Nature.com
2023-10-20 07:00 YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions - Nature.com
2023-01-31 08:00 HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease - ScienceDirect.com
2021-06-07 07:00 A small molecule HIF-1α stabilizer that accelerates diabetic wound healing - Nature.com
2022-03-03 00:30 RETRACTED: Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization - pnas.org
2019-11-01 07:00 Mechanism and Consequences of The Impaired Hif-1α Response to Hypoxia in Human Proximal Tubular HK-2 Cells Exposed to High Glucose - Nature.com
2022-03-03 17:38 Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways - pnas.org
2018-11-12 08:00 Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage - Nature.com

2021-09-16 05:52 Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling - Science
2016-01-13 08:00 Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis - Nature.com
2019-11-14 08:00 Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms - Nature.com
2017-11-02 07:00 HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy - Nature.com
2023-10-27 07:00 MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy | Circulation - AHA Journals
2015-12-14 08:00 HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond - Nature.com
2019-02-26 08:00 Trophoblast-Specific Expression of Hif-1α Results in Preeclampsia-Like Symptoms and Fetal Growth Restriction - Nature.com
2014-10-09 07:00 Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation - ScienceDirect.com
2023-04-05 07:00 MOU with HIF Global for Strategic Partnership in the Field of e-fuels | List of news releases | Idemitsu Kosan - 出光興産
2022-05-09 07:00 Identification of oleoylethanolamide as an endogenous ligand for HIF-3α - Nature.com

2023-06-09 19:55 Hypoxia inducible factor-1α is an important regulator of macrophage biology - ScienceDirect.com
2023-01-17 08:00 Correction: HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis - Nature.com
2019-08-07 07:00 CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension - Nature.com
2021-09-17 22:25 Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch - Science
2017-09-11 07:00 Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma - Nature.com
2017-07-31 07:00 UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization - Nature.com
2022-02-01 08:00 Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers - ScienceDirect.com
2018-09-12 07:00 Stabilization of HIF-2α impacts pancreas growth - Nature.com
2017-09-18 07:00 The HIF and other quandaries in VHL disease - Oncogene - Nature.com
2021-06-21 07:00 The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes - Nature.com

2016-06-30 07:00 A HIF- 1α -driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT - Nature.com

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